Gene Circuitry Controlling a Stem Cell Niche

@article{Chen2005GeneCC,
  title={Gene Circuitry Controlling a Stem Cell Niche},
  author={Dahua Chen and Dennis M. McKearin},
  journal={Current Biology},
  year={2005},
  volume={15},
  pages={179-184}
}
Many stem cell populations interact with stromal cells via signaling pathways, and understanding these interactions is key for understanding stem cell biology. In Drosophila, germline stem cell (GSC) maintenance requires regulation of several genes, including dpp, piwi, pumilio, and bam. GSCs also maintain continuous contact with cap cells that probably secrete the signaling ligands necessary for controlling expression of these genes. For example, dpp signaling acts by silencing transcription… CONTINUE READING
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