Gene × Environment Interactions at the Serotonin Transporter Locus

@article{Munafo2009GeneE,
  title={Gene × Environment Interactions at the Serotonin Transporter Locus},
  author={M. Munafo and C. Durrant and G. Lewis and J. Flint},
  journal={Biological Psychiatry},
  year={2009},
  volume={65},
  pages={211-219}
}
BACKGROUND Although it is universally accepted that human disease and behavior depend upon both environmental and genetic variation, a view supported by family and twin studies, examples of environmental interactions with genes identified at the molecular level (G x E) are not so well established. METHODS We carried out a systematic review and meta-analysis of the serotonin transporter (5-HTTLPR) polymorphic region x stressful life event (SLE) literature and investigated to what extent the… Expand
Serotonin transporter gene: will epigenetics prove less depressing than genetics?
TLDR
Differences in depressive symptoms were correlated with differences in methylation status, such that higher methylation, which, in this sample of identical twins, must be environmental in origin, is associated with more depressive symptoms. Expand
Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits.
TLDR
Research is reviewed about variation in the promoter region of the serotonin transporter gene (SLC6A4) and its contribution to stress sensitivity and the contribution of GxE research to the public understanding of genetic science. Expand
No interaction between serotonin transporter gene (5-HTTLPR) polymorphism and adversity on depression among Japanese children and adolescents
TLDR
Binary logistic regression analyses revealed that maternal depression (adversity), gender, and FSIQ significantly affect the diagnosis of depression among children and adolescents, however, no main effect was found for adversity or genotype. Expand
Title No interaction between serotonin transporter gene ( 5-HTTLPR ) polymorphism and adversity on depression among Japanese children and adolescents
Background: Identification of gene × environment interactions (G × E) for depression is a crucial step in ascertaining the mechanisms underpinning the disorder. Earlier studies have indicated strongExpand
Current developments and controversies: does the serotonin transporter gene-linked polymorphic region (5-HTTLPR) modulate the association between stress and depression?
TLDR
Convergent evidence is accumulating from different research fields that 5-HTTLPR is indeed closely associated with different biological pathways associated with stress regulation and depression. Expand
THE SEROTONIN TRANSPORTER GENE AND DEPRESSION
TLDR
It is unlikely that the serotonin transporter gene plays a major role in depression, and the genetic architecture of common disease phenotypes such as depression comprises a very large number of common variants of very small effect, possibly together with a smaller number of rare variants of larger effect. Expand
The role of the serotonin transporter gene, brain structure and family environment in the emergence of depression during adolescence
TLDR
This thesis aims to enhance current understanding of this interaction by considering how two different dimensions of environmental experience (threat versus deprivation) might interact with the serotonin transporter gene during adolescence, while also investigating potential underlying neurobiological mechanisms. Expand
Gene × environment interaction models in psychiatric genetics.
  • Katja Karg, S. Sen
  • Biology, Medicine
  • Current topics in behavioral neurosciences
  • 2012
TLDR
This article discusses recent developments in G × E interaction research on the most heavily investigated example in psychiatric genetics, the interaction between a serotonin transporter gene promoter variant and stress on depression. Expand
Gene environment interaction studies in depression and suicidal behavior: An update
TLDR
The literature regarding the interaction between genes modulating brain functions and stressful life events in the etiology of MD and SB is reviewed and their potential added benefit compared to genetic studies only is discussed. Expand
Refining the Candidate Environment
TLDR
It is proposed that the candidate environment (akin to a candidate gene) is key in the interaction between life stress and the serotonin transporter–linked polymorphism (5-HTTLPR) on depression, and identified such candidate environments may facilitate future gene-environment research in depression and psychopathology more broadly. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 34 REFERENCES
The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis
TLDR
While the G × E has been consistently detected in young adult samples, there are contradictory findings in adolescent boys and elderly people and the method of assessment of environmental adversity is also important with detailed interview-based approaches being associated with positive G ×E findings. Expand
The Serotonin Transporter Length Polymorphism, Neuroticism, and Depression: A Comprehensive Assessment of Association
TLDR
The data do not support the hypothesis that the 5-HTTLPR variant contributes significantly toward human emotionality as indexed by either the Eysenck Personality Questionnaire N scale or the DSM-IV for MD. Expand
Gene–environment interaction analysis of serotonin system markers with adolescent depression
TLDR
There was a significant genotype–environmental risk interaction for 5HTTLPR in female subjects only, with the effect being in the same direction as another recent study, reaffirming that an important source of genetic heterogeneity is exposure to environmental risk. Expand
Serotonin Transporter Gene Polymorphism (5-HTTLPR) and Anxiety Reactivity in Daily Life: A Daily Process Approach to Gene-Environment Interaction
TLDR
These findings highlight the potential value of focusing on genetic vulnerability in the context of everyday environmental triggers, and argue that genotype differences in anxiety should be stronger in the presence of stress. Expand
Development of depression: sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene.
TLDR
The results suggest that both the molecular and the psychosocial mechanisms underlying depression may differ between boys and girls and that males seem to be protected from depression. Expand
Meta-analysis of serotonin transporter polymorphisms and affective disorders
TLDR
The results suggest that the S allele, or a neighboring allele in linkage disequilibrium, is recessive for MDD and possibly BPD, and with these small associations, confounding issues such as population stratification require addressing. Expand
Genotype × Environment Interaction in Psychopathology: Fact or Artifact?
  • L. Eaves
  • Medicine
  • Twin Research and Human Genetics
  • 2006
TLDR
There is reason to question the biological significance of published findings after simulated liabilities and diagnoses of major depression and antisocial behavior were simulated. Expand
Life events, first depression onset and the serotonin transporter gene
TLDR
The 5-HTTLPR genotype is a significant predictor of onset of major depression following multiple adverse events and is one of the more robust findings concerning specific biological risk factors for depression. Expand
The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication.
TLDR
Variation at the 5-HTT moderates the sensitivity of individuals to the depressogenic effects of SLEs largely by producing, in SS individuals, an increased sensitivity to the impact of mild stressors. Expand
Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden
TLDR
The results partly confirm previous findings of a significant gene–environment interaction of the short allele, indicating a higher mental vulnerability to social stressors and chronic diseases. Expand
...
1
2
3
4
...