Gene × Environment Interactions at the Serotonin Transporter Locus

@article{Munaf2009GeneE,
  title={Gene × Environment Interactions at the Serotonin Transporter Locus},
  author={M. Munaf{\`o} and C. Durrant and G. Lewis and J. Flint},
  journal={Biological Psychiatry},
  year={2009},
  volume={65},
  pages={211-219}
}
  • M. Munafò, C. Durrant, +1 author J. Flint
  • Published 2009
  • Psychology, Medicine
  • Biological Psychiatry
  • BACKGROUND Although it is universally accepted that human disease and behavior depend upon both environmental and genetic variation, a view supported by family and twin studies, examples of environmental interactions with genes identified at the molecular level (G x E) are not so well established. METHODS We carried out a systematic review and meta-analysis of the serotonin transporter (5-HTTLPR) polymorphic region x stressful life event (SLE) literature and investigated to what extent the… CONTINUE READING
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    References

    SHOWING 1-10 OF 34 REFERENCES
    The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis
    • 499
    • PDF
    Gene–environment interaction analysis of serotonin system markers with adolescent depression
    • 644
    • Highly Influential
    • PDF
    Development of depression: sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene.
    • 249
    • PDF
    Meta-analysis of serotonin transporter polymorphisms and affective disorders
    • 257
    Life events, first depression onset and the serotonin transporter gene.
    • 299
    • PDF
    Mental and physical distress is modulated by a polymorphism in the 5-HT transporter gene interacting with social stressors and chronic disease burden
    • 279
    • PDF