Gene–environment interactions in psychiatry: joining forces with neuroscience

@article{Caspi2006GeneenvironmentII,
  title={Gene–environment interactions in psychiatry: joining forces with neuroscience},
  author={Avshalom Caspi and Terrie E. Moffitt},
  journal={Nature Reviews Neuroscience},
  year={2006},
  volume={7},
  pages={583-590}
}
Gene–environment interaction research in psychiatry is new, and is a natural ally of neuroscience. Mental disorders have known environmental causes, but there is heterogeneity in the response to each causal factor, which gene–environment findings attribute to genetic differences at the DNA sequence level. Such findings come from epidemiology, an ideal branch of science for showing that gene–environment interactions exist in nature and affect a significant fraction of disease cases. The… 
Gene-Environment Interactions in Psychiatry: Recent Evidence and Clinical Implications
TLDR
Gene-by-environment interaction research in psychiatry globally suggests some susceptibility to environmental exposures based on genotype; however, greater clarity is needed around the idea that genetic risk may not be disorder specific.
Animal models of gene–environment interactions in schizophrenia
TLDR
It is proposed that animal models based on identified genetic mutations and measurable environment factors will help advance studies of the molecular mechanisms of gene-environment interplay in schizophrenia.
Forum: The case for gene-environment interactions in psychiatry.
  • R. Uher
  • Psychology, Medicine
    Current opinion in psychiatry
  • 2008
TLDR
A case is made for G E as these interactions are likely to be common, detectable, replicable and beneficial to basic and applied research.
Gene–Environment Interactions for Searchers: Collaboration between Epidemiology and Molecular Genetics
Attempts to discover genes that relate directly to psychotic disorder (i.e., the simple “main effects” approach) have been frustrating and often disappointing, resulting in the expression of
Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions.
TLDR
Experimental ecogenetic approaches with randomized assignment may help to overcome some of the limitations of observational studies and allow for the additional elucidation of underlying mechanisms using a combination of functional enviromics and functional genomics.
Mechanisms of Gene-Environment Interaction Effects in the Development of Conduct Disorder
  • K. Dodge
  • Psychology, Medicine
    Perspectives on psychological science : a journal of the Association for Psychological Science
  • 2009
TLDR
A model of these processes that focuses on the individual's response to a threatening stimulus in ongoing social interaction is proposed, which can serve as a template for inquiry in other forms of developmental psychopathology.
REVIEW: HPA‐axis activity in alcoholism: examples for a gene–environment interaction
TLDR
The findings of the studies discussed here suggest that the collaborations of neuroscience, psychobiology and molecular genetics provide a promising framework to elucidate the exact mechanisms of gene–environment interactions as seen to convene upon the HPA axis and effect phenotypes of addiction.
Misconceptions about gene–environment interactions in psychiatry
Misunderstandings surrounding the study of gene–environment interactions are very common. Given the large increase in the number of studies examining interactions in recent years, this raises serious
Gene × environment interaction models in psychiatric genetics.
  • Katja Karg, S. Sen
  • Biology, Medicine
    Current topics in behavioral neurosciences
  • 2012
TLDR
This article discusses recent developments in G × E interaction research on the most heavily investigated example in psychiatric genetics, the interaction between a serotonin transporter gene promoter variant and stress on depression.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 152 REFERENCES
Measured Gene-Environment Interactions in Psychopathology
  • T. Moffitt, A. Caspi, M. Rutter
  • Psychology, Medicine
    Perspectives on psychological science : a journal of the Association for Psychological Science
  • 2006
TLDR
It is suggested that information about nurture might be harnessed to make new discoveries about the nature of psychopathology and the potential benefits of studying measured gene-environment interactions for basic neuroscience, gene hunting, intervention, and public understanding of genetics.
Gene-environment interplay and psychopathology: multiple varieties but real effects.
TLDR
This review of research evidence on four varieties of gene-environment interplay considers epigenetic mechanisms by which environmental influences alter the effects of genes and focuses on variations in heritability according to environmental circumstances.
Gene–environment interactions in human diseases
  • D. Hunter
  • Biology, Medicine
    Nature Reviews Genetics
  • 2005
TLDR
Suggestions are made for improvements in the study of study design, sample size and genotyping technology, which influence the analysis and interpretation of observed gene–environment interactions.
Strategy for investigating interactions between measured genes and measured environments.
TLDR
It is suggested that in psychiatric genetics, ignoring nurture handicaps the field's capacity to make new discoveries about nature and the potential benefits of the measured-GxE approach for basic neuroscience and for gene hunting are explained.
Genes, environment and schizophrenia.
TLDR
Schizotaxia provides a useful way to conceptualise both the liability for schizophrenia, and also the development of treatment strategies aimed at the eventual prevention of the illness.
Behavioral genetics in the postgenomic era
Behavioral Genetics The Role of Molecular Genetics in a Post Genomics World Recent Developments in Quantitative Trait Loci Analysis Practical Barriers to Identifying Complex Trait Loci Assessing
The new look of behavioral genetics in developmental psychopathology: gene-environment interplay in antisocial behaviors.
  • T. Moffitt
  • Psychology, Medicine
    Psychological bulletin
  • 2005
TLDR
Behavioral-genetic research can help address questions of causation in developmental psychopathology, and future work on gene-environment interplay is envisaged, arguing that it is an interesting and profitable way forward for psychopathology research.
Effects of the interaction between genotype and environment. Research into the genetic epidemiology of alcohol dependence.
TLDR
Understanding the contributions of GxE interaction effects to the risk for and development of alcohol dependence and coexisting disorders is of paramount importance and can be determined by appropriately designed family and molecular epidemiological measures.
Genetic tests of biologic systems in affective disorders
TLDR
Five groupings of genes implicated by neuropharmacological and other evidence are presented, which suggest 252 candidate genes worth examining and can readily exploit information on genomic sequence variations obtained from databases and/or resequencing, and has an advantage of not having the complication of an extremely stringent statistical criterion for association.
...
1
2
3
4
5
...