Gene–Environment Interactions: A Review of Effects on Reproduction and Development

  title={Gene–Environment Interactions: A Review of Effects on Reproduction and Development},
  author={A. Cummings and R. Kavlock},
  journal={Critical Reviews in Toxicology},
  pages={461 - 485}
  • A. Cummings, R. Kavlock
  • Published 2004
  • Biology, Medicine
  • Critical Reviews in Toxicology
  • ABSTRACT Polymorphisms in genes can lead to differences in the level of susceptibility of individuals to potentially adverse effects of environmental influences, such as chemical exposure, on prenatal development or male or female reproductive function. We have reviewed the literature in this area, with the caveat that papers involving straight gene knock-outs in experimental animals, without a clear human relevance, were largely excluded. This review represents current knowledge in this… CONTINUE READING
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