Gene–Environment Interactions: A Review of Effects on Reproduction and Development

@article{Cummings2004GeneEnvironmentIA,
  title={Gene–Environment Interactions: A Review of Effects on Reproduction and Development},
  author={A. Cummings and R. Kavlock},
  journal={Critical Reviews in Toxicology},
  year={2004},
  volume={34},
  pages={461 - 485}
}
  • A. Cummings, R. Kavlock
  • Published 2004
  • Biology, Medicine
  • Critical Reviews in Toxicology
  • ABSTRACT Polymorphisms in genes can lead to differences in the level of susceptibility of individuals to potentially adverse effects of environmental influences, such as chemical exposure, on prenatal development or male or female reproductive function. We have reviewed the literature in this area, with the caveat that papers involving straight gene knock-outs in experimental animals, without a clear human relevance, were largely excluded. This review represents current knowledge in this… CONTINUE READING
    57 Citations
    Metabolic and genetic factors contributing to alcohol induced effects and fetal alcohol syndrome
    • 56
    An Update on Fetal Alcohol Syndrome-Pathogenesis, Risks, and Treatment.
    • 66

    References

    SHOWING 1-10 OF 201 REFERENCES
    ADH2 and CYP2E1 genetic polymorphisms: risk factors for alcohol-related birth defects.
    • D. G. McCarver
    • Biology, Medicine
    • Drug metabolism and disposition: the biological fate of chemicals
    • 2001
    • 43
    • PDF
    Genetic susceptibility to benzene and shortened gestation: evidence of gene-environment interaction.
    • 77
    • PDF
    Gene-environment interaction: definitions and study designs.
    • R. Ottman
    • Biology, Medicine
    • Preventive medicine
    • 1996
    • 153
    • PDF
    Drug-Metabolizing Enzymes, Polymorphisms and Interindividual Response to Environmental Toxicants
    • D. Nebert
    • Biology, Medicine
    • Clinical chemistry and laboratory medicine
    • 2000
    • 54
    Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome.
    • 321
    • PDF
    Alcohol dehydrogenase-2*3 allele protects against alcohol-related birth defects among African Americans.
    • 136
    • PDF
    Polymorphisms in biotransformation enzymes and the risk for recurrent early pregnancy loss.
    • 63
    • PDF