Gene, ethnic and gender influences predisposition of adverse drug reactions to artesunate among Malaysians.

@article{Yusof2012GeneEA,
  title={Gene, ethnic and gender influences predisposition of adverse drug reactions to artesunate among Malaysians.},
  author={Wardah Yusof and Gan Siew Hua},
  journal={Toxicology mechanisms and methods},
  year={2012},
  volume={22 3},
  pages={184-92}
}
CONTEXT Artesunate (AS) and amodiaquine (AQ) are two prodrugs widely used as antimalarial agents and are metabolized by the CYP P450 2A6 (CYP 2A6) and CYP P450 2C8 (CYP 2C8) enzymes, respectively. OBJECTIVE In this study, we aim to investigate the association of both genes on AS and AQ's tolerabilities in the hope of identifying a pharmacogenetic approach that could be useful in prediction and prevention of adverse drug reactions (ADRs) among Malaysian population. MATERIALS AND METHODS In… CONTINUE READING

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