Gender variability in presentation with Alpers’ syndrome: a report of eight patients from the UAE


Alpers’ syndrome is a progressive and often fatal cerebral and hepatic degeneration caused by a mutation in the polymerase gamma (POLG) gene involved in mitochondrial DNA replication. We report on eight successive cases from five families. Our analysis consisted of case series reports and literature search. The eight patients were from five extended… (More)
DOI: 10.1007/s10545-011-9278-8