Gender specificity in the genetic determinants of peak bone mass.

  title={Gender specificity in the genetic determinants of peak bone mass.},
  author={Eric S. Orwoll and John K. Belknap and Robert F. Klein},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={16 11},
Peak bone mass is a major determinant of osteoporotic fracture risk. Gender differences in peak bone mass acquisition are well recognized in humans and may account for a substantial share of the increased prevalence of fragility fractures in women compared with men. Skeletal development is regulated by both heritable and environmental factors. Experimental animal models provide a means to circumvent complicating environmental factors. In this study we examined the heritability of peak bone… CONTINUE READING


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