Gender-specific roles for the melanocortin-3 receptor in the regulation of the mesolimbic dopamine system in mice.

@article{Lippert2014GenderspecificRF,
  title={Gender-specific roles for the melanocortin-3 receptor in the regulation of the mesolimbic dopamine system in mice.},
  author={Rachel N Lippert and Kate L. J. Ellacott and Roger D Cone},
  journal={Endocrinology},
  year={2014},
  volume={155 5},
  pages={1718-27}
}
The melanocortin-3 receptor (MC3R) and MC4R are known to play critical roles in energy homeostasis. However, the physiological functions of the MC3R remain poorly understood. Earlier reports indicated that the ventral tegmental area (VTA) is one of the highest sites of MC3R expression, and we sought to determine the function of the receptor in this brain region. A MC3R-green-fluorescent protein transgenic mouse and a MC3R knockout mouse strain were used to characterize the neurochemical… CONTINUE READING
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