Gender specific requirement of GluR1 receptors in contextual conditioning but not spatial learning.

Abstract

The GluR1 subunit of the AMPA receptor is required for hippocampal-dependent memory formation, emotional learning and synaptic plasticity. Recent work has shown that GluR1-independent synaptic plasticity is mediated by nitric oxide. Nitric oxide activity is influenced by estrogen. It is unknown whether this gender-dependent effect conveys a gender dimorphic… (More)
DOI: 10.1016/j.nlm.2011.07.001

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