Gender-specific regulation of mitochondrial fusion and fission gene transcription and viability of cortical astrocytes by steroid hormones.

@article{Arnold2008GenderspecificRO,
  title={Gender-specific regulation of mitochondrial fusion and fission gene transcription and viability of cortical astrocytes by steroid hormones.},
  author={Susanne Arnold and Gilda Wright de Ara{\'u}jo and Cordian Beyer},
  journal={Journal of molecular endocrinology},
  year={2008},
  volume={41 5},
  pages={
          289-300
        }
}
Astroglia and steroid hormones such as estrogen and progesterone regulate cell growth, function, and protection in the central nervous system (CNS). It appears that astrocytes and steroids act in concert to promote cell survival under pathological conditions. With respect to the role of mitochondrial fusion and fission in energy metabolism, apoptosis, and proliferation, astrocyte mitochondria resemble a perfect intracellular target for steroids to modulate these processes, thereby promoting… CONTINUE READING

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