Gender-specific proteomic alterations in glycolytic and mitochondrial pathways in aging monkey hearts.

  title={Gender-specific proteomic alterations in glycolytic and mitochondrial pathways in aging monkey hearts.},
  author={Lin Yan and Hui Ge and Hongliang Li and Samuel C. Lieber and F. Natividad and Ranillo R. G. Resuello and S Kim and S Akeju and Aijun Sun and K C Loo and Athanasios P Peppas and Franco Schmidt Rossi and E Douglas Lewandowski and A. P. Thomas and Stephen F. Vatner and Dorothy E. Vatner},
  journal={Journal of molecular and cellular cardiology},
  volume={37 5},
We utilized proteomic techniques in a primate model (Macaca fascicularis) of aging to determine potential mechanisms to explain gender differences in protection of the aging heart. The majority of prior work in this field utilized rodent models, and importantly no prior study utilized a proteomic approach in the aging heart. We studied changes in proteins in seven monkeys in each group (young and old males and females (YMs, OMs, YFs, and OFs, respectively)), and used two-dimensional gel… CONTINUE READING
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