Gender-specific hypertension and responsiveness to nitric oxide in sGCalpha1 knockout mice.

@article{Buys2008GenderspecificHA,
  title={Gender-specific hypertension and responsiveness to nitric oxide in sGCalpha1 knockout mice.},
  author={Emmanuel S Buys and Patrick Y Sips and Pieter Vermeersch and Michael J. Raher and Elke Rogge and Fumito Ichinose and Mieke Dewerchin and Kenneth D. Bloch and Stefan Janssens and P. G. G. Brouckaert},
  journal={Cardiovascular research},
  year={2008},
  volume={79 1},
  pages={
          179-86
        }
}
AIM The effects of nitric oxide (NO) in the cardiovascular system are attributed in part to cGMP synthesis by the alpha1beta1 isoform of soluble guanylate cyclase (sGC). Because available sGC inhibitors are neither enzyme- nor isoform-specific, we generated knockout mice for the alpha1 subunit (sGCalpha1(-/-) mice) in order to investigate the function of sGCalpha1beta1 in the regulation of blood pressure and cardiac function. METHODS AND RESULTS Blood pressure was evaluated, using both non… CONTINUE READING
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