Gender specific differences in the liver proteome of rats exposed to short term and low-concentration hexabromocyclododecane (HBCD).

@article{Miller2016GenderSD,
  title={Gender specific differences in the liver proteome of rats exposed to short term and low-concentration hexabromocyclododecane (HBCD).},
  author={I. George Miller and Coos Diepenbroek and Eddy Rijntjes and Jenny Renaut and Katja J Teerds and Christiaan J. A. F. Kwadijk and S{\'e}bastien Cambier and A J Murk and A. C. Gutleb and Tommaso Serchi},
  journal={Toxicology research},
  year={2016},
  volume={5 5},
  pages={
          1273-1283
        }
}
The influence of short term (7-day) exposure of male rats to the brominated flame retardant hexabromocyclododecane (HBCD) was studied by investigation of the liver proteome, both in euthyroid and hypothyroid rats and by comparing results with general data on animal physiology and thyroid hormone, leptin, insulin and gonadotropin concentrations determined in parallel. Proteome analysis of liver tissue by two-dimensional fluorescence difference gel electrophoresis (2D-DIGE) revealed that only… CONTINUE READING
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