Gender-specific approach in psychiatric diseases: because sex matters.

  title={Gender-specific approach in psychiatric diseases: because sex matters.},
  author={Anna Franceschini and Liana Fattore},
  journal={European journal of pharmacology},
How Can Animal Models Inform the Understanding of Cognitive Inflexibility in Patients with Anorexia Nervosa?
The activity-based anorexia (ABA) model recapitulates the key features of AN in human patients, including rapid weight loss caused by self-starvation and hyperactivity, supporting its application in investigating the cognitive and neurobiological causes of pathological weight loss.
Behavior and Fos activation reveal that male and female rats differentially assess affective valence during CTA learning and expression
The present study suggests that males and females differentially process the affective valence of a stimulus to produce the same goal-directed behavior.
Protease-activated receptor 2 activation induces behavioural changes associated with depression-like behaviour through microglial-independent modulation of inflammatory cytokines
Data reveal that PAR2 activation results in behavioural changes often associated with depression-like behaviour and an inflammatory profile that resembles that seen in patients with MDD and therefore PAR2 may be a target for novel antidepressant therapies.
P.0241 Deficiency of the ywhaz gene, involved in neurodevelopmental disorders, alters brain activity and behaviour in zebrafish
An important role for ywhaz in establishing neuronal connectivity during developmental stages is suggested, which leads to impaired dopamine and serotonin neurotransmission that may underlie the altered behaviour observed during adulthood.
Methods to Develop an in silico Clinical Trial: Computational Head-to-Head Comparison of Lisdexamfetamine and Methylphenidate
A mechanistic head-to-head in silico clinical trial between two treatments for attention-deficit/hyperactivity disorder, to wit lisdexamfetamine (LDX) and methylphenidate (MPH).
Bacterial sensing via neuronal Nod2 regulates appetite and body temperature
The finding that Nod2 was expressed in neurons of several brain regions including the hypothalamus in reporter mice suggests that the brain may sense changes in gut bacteria as a measure of food intake and could serve as the basis for future neurologic and metabolic therapies.
Kisspeptin in the Limbic System: New Insights Into Its Neuromodulatory Roles.


Sex differences in animal models of psychiatric disorders
The need for the inclusion of both male and female animals in experimental studies aiming at gender‐oriented prevention, diagnosis and treatment of psychiatric disorders is highlighted.
Sex, hormones, and genotype interact to influence psychiatric disease, treatment, and behavioral research
Evidence supporting the inclusion of males and females at all levels of neuroscience research is highlighted and how genes interact with sex to influence disease risk and treatment is argued.
Sexual dimorphism in schizophrenia: is there a need for gender-based protocols?
This research will help to identify individuals who may benefit greatest from adjunct hormonal therapies and will further the understanding of the etiology of schizophrenia and other psychiatric disorders.
Gender differences in schizophrenia
  • H. Häfner
  • Medicine, Psychology
  • 2003
Biological factors underlying sex differences in neurological disorders.
Animal models of anxiety and depression: how are females different?
  • P. Palanza
  • Psychology, Biology
    Neuroscience & Biobehavioral Reviews
  • 2001
Sex and gender differences in schizophrenic psychoses—a critical review
More methodologically sound, longitudinal, multi-domain, interdisciplinary research is required to better understand the different pathogenesis and etiologies of schizophrenic psychoses in women and men, thereby leading to better tailored treatments and improved outcomes.
Sex-specific issues in eating disorders: a clinical and psychopathological investigation
Male ED, compared to female ED, show differences in clinical presentation, symptoms and co-morbidities, and sex differences do exist and additional studies are required to investigate male specific issues in ED.
Sex/gender differences in the brain and cognition in schizophrenia