Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis

@article{Savettieri2004GenderrelatedEO,
  title={Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis},
  author={Giovanni Savettieri and Demetrio Messina and Virginia Andreoli and Simona Bonavita and Carlo Caltagirone and Rita Cittadella and Deborah Farina and Maria Carolina Fazio and Paolo Girlanda and Francesco Le Pira and Maria Liguori and Alessandra Lugaresi and Ugo Nocentini and Arturo Reggio and Giuseppe Salemi and Gioacchino Tedeschi and Maria Trojano and Paola Valentino and Alessandro Quattrone},
  journal={Journal of Neurology},
  year={2004},
  volume={251},
  pages={1208-1214}
}
Abstract.Background:Cognitive impairment may occur at any time during the course of multiple sclerosis (MS), and it is often a major cause of disability in patients with the disease. The APOE-ε4 allele is the major known genetic risk factor for late onset familial and sporadic Alzheimer’s Disease (AD), and it seems to be implicated in cognitive decline in normal elderly persons.Objective:To investigate the clinical and genetic variables that can be associated with the cognitive decline in… CONTINUE READING

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