Gender related differences in treatment and response to statins in primary and secondary cardiovascular prevention: The never‐ending debate

@article{Cangemi2017GenderRD,
  title={Gender related differences in treatment and response to statins in primary and secondary cardiovascular prevention: The never‐ending debate},
  author={Roberto Cangemi and Giulio Francesco Romiti and Giuseppe Campolongo and Eleonora Ruscio and Susanna Sciomer and Daniele Gianfrilli and Valeria Raparelli},
  journal={Pharmacological Research},
  year={2017},
  volume={117},
  pages={148–155}
}
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References

SHOWING 1-10 OF 84 REFERENCES
Impact of gender in primary prevention of coronary heart disease with statin therapy: a meta-analysis.
Gender-related lipid and/or lipoprotein responses to statins in subjects in primary and secondary prevention.
Statin therapy in the prevention of recurrent cardiovascular events: a sex-based meta-analysis.
TLDR
Statin therapy is an effective intervention in the secondary prevention of cardiovascular events in both sexes, but there is no benefit on stroke and all-cause mortality in women.
Advances in Lipid Therapy: The Role of Lipid Treatment in Women in Primary Prevention.
Gender differences in treatment of cardiovascular disease: a task force on gender of the ESC proposal on gender specific studies in cardiovascular pharmacology
TLDR
In this issue Lombardi et al. will discuss the gender-specific aspects of primary and secondary prevention showing how interventions effective in one sex may have different of lower effect in the other.
Meta-analysis of statin effects in women versus men.
Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174 000 participants in 27 randomised trials
The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials
TLDR
In patients without established cardiovascular disease but with cardiovascular risk factors, statin use was associated with significantly improved survival and large reductions in the risk of major cardiovascular events.
Statins and all-cause mortality in high-risk primary prevention: a meta-analysis of 11 randomized controlled trials involving 65,229 participants.
TLDR
This literature-based meta-analysis did not find evidence for the benefit of statin therapy on all-cause mortality in a high-risk primary prevention set-up.
Gender in cardiovascular diseases: impact on clinical manifestations, management, and outcomes.
TLDR
The term S&G is used for all medical relevant differences between women and men in the present review to include the inclusion of the gender dimension into biomedical research since ‘it helps improve the scientific quality …’.
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