Gender-related differences in susceptibility of A/J mouse to benzo[a]pyrene-induced pulmonary and forestomach tumorigenesis.

@article{Singh1998GenderrelatedDI,
  title={Gender-related differences in susceptibility of A/J mouse to benzo[a]pyrene-induced pulmonary and forestomach tumorigenesis.},
  author={Shivendra V Singh and Peter J. Benson and Xiaojian Hu and Ajai Pal and Huili Xia and Sanjay Kumar Srivastava and Sanjay Awasthi and Howard A. Zaren and John L. Orchard and Yogesh C. Awasthi},
  journal={Cancer letters},
  year={1998},
  volume={128 2},
  pages={197-204}
}
Benzo[a]pyrene (BP) is a suspected human carcinogen and is known to produce tumors in the lung and forestomach of mice. Glutathione (GSH) S-transferases (GST) play a major role in the detoxification of the ultimate carcinogen of BP, (+)-anti-7,8-dihydroxy-9,10-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene ((+)-anti-BPDE). Previous studies have shown gender-related differences in the expression of GST isoenzymes in mice. The present study was designed to test the hypothesis whether gender-related… CONTINUE READING

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