Gender-related differences in myocardial inflammatory and contractile responses to major burn trauma.

@article{Horton2004GenderrelatedDI,
  title={Gender-related differences in myocardial inflammatory and contractile responses to major burn trauma.},
  author={Jureta W. Horton and D. Jean White and David L. Maass},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2004},
  volume={286 1},
  pages={
          H202-13
        }
}
Gender-related differences in immune responses to hemorrhage and sepsis have been described. However, most trauma studies continue to limit experimental models to males to avoid the variable responses associated with hormonal fluctuation in proestrus/estrus females. In the present study, male and female (either diestrus or proestrus/estrus) Sprague-Dawley rats (250-325 g) were given a third-degree scald burn over 40% total body surface area and fluid resuscitated (4 ml/kg per %burn of lactated… 
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EFFECTS OF BURN SERUM ON MYOCARDIAL INFLAMMATION AND FUNCTION

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Role of endogenous testosterone in TNF-induced myocardial injury in males.

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References

SHOWING 1-10 OF 54 REFERENCES

Burn-Induced Impairment of Cardiac Contractile Function Is Due to Gut-Derived Factors Transported in Mesenteric Lymph

Burn-induced cardiac dysfunction, manifested by impaired contraction and relaxation, is prevented by pre-burn lymph duct ligation, which indicates that gut-derived myocardial depressant factors transported in mesenteric lymph contribute to burn-induced impairment of cardiac contractile function.

Effects of fluid resuscitation on cardiac dysfunction following thermal injury.

Inhibition of tumor necrosis factor prevents myocardial dysfunction during burn shock.

Cardiac function was compared in 49 guinea pigs 18 h after thermal injury to determine whether TNF is responsible for postburn myocardial dysfunction and TNF inhibitor was shown to specifically bind and neutralize TNF secreted by guinea pig peritoneal macrophages in vitro.

Hypertonic saline-dextran suppresses burn-related cytokine secretion by cardiomyocytes.

The data suggest that HSD mediates cardioprotection after burn trauma, in part, by downregulating cardiomyocyte secretion of inflammatory cytokines.

Sex steroids regulate pro- and anti-inflammatory cytokine release by macrophages after trauma-hemorrhage.

The results suggest that male and female sex steroids exhibit divergent immunomodulatory properties with respect to cell-mediated immune responses after trauma-hemorrhage.

Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males.

Results indicate that left ventricular performance, cardiac output, HMBF, and hepatocellular function decreased significantly at 20 h after the completion of trauma, hemorrhage, and resuscitation.

Sex differences in posttraumatic cytokine release of endotoxin-stimulated whole blood: relationship to the development of severe sepsis.

A sex-specific regulation of leukocyte function in patients with multiple injuries within the early posttraumatic period is demonstrated and may correspond to enhanced inflammatory responses, which increase susceptibility to sepsis, whereas in female patients, other regulatory mechanisms may be involved.

Enhanced immune responses in females, as opposed to decreased responses in males following haemorrhagic shock and resuscitation.

This is the first study which shows that immune responsiveness in female mice is enhanced after haemorrhagic shock, as opposed to decreased responsiveness in males, suggesting that females should be able to better tolerate the deleterious effects of shock.

Gender differences in human sepsis.

Gender differences were confirmed in human sepsis, with a significantly better prognosis for women, which may be related to increased levels of anti-inflammatory mediators.

Sex and estrogens in protection against circulatory stress reactions.

  • B. Altura
  • Biology, Medicine
    The American journal of physiology
  • 1976
The data reported herein could be used to suggest that estrogenic hormones may play pivotal roles in a) the amelioration of an organism's reaction to systemic stress; and b) control of macrophage and peripheral vascular functions.
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