Gender-related differences in myocardial inflammatory and contractile responses to major burn trauma.

  title={Gender-related differences in myocardial inflammatory and contractile responses to major burn trauma.},
  author={Jureta W. Horton and D. Jean White and David L. Maass},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={286 1},
Gender-related differences in immune responses to hemorrhage and sepsis have been described. However, most trauma studies continue to limit experimental models to males to avoid the variable responses associated with hormonal fluctuation in proestrus/estrus females. In the present study, male and female (either diestrus or proestrus/estrus) Sprague-Dawley rats (250-325 g) were given a third-degree scald burn over 40% total body surface area and fluid resuscitated (4 ml/kg per %burn of lactated… 

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  • B. Altura
  • Biology, Medicine
    The American journal of physiology
  • 1976
The data reported herein could be used to suggest that estrogenic hormones may play pivotal roles in a) the amelioration of an organism's reaction to systemic stress; and b) control of macrophage and peripheral vascular functions.