Gender modulates cardiac phenotype development in genetically modified mice.

  title={Gender modulates cardiac phenotype development in genetically modified mice.},
  author={X J Du},
  journal={Cardiovascular research},
  volume={63 3},
  • X J Du
  • Published 2004 in Cardiovascular research
Recent research using genetically modified mice has revealed significant sex differences in cardiac phenotypes. In the majority of strains, females display a lower mortality, less severe hypertrophy, better preserved function and mitigated cardiac pathology compared with male counterparts. Thus, gender is an independent determinant for the development of cardiac phenotype in murine models. While there is strong evidence for estrogen as a cardiac protector, emerging evidence indicates adverse… CONTINUE READING

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