Gender-linked hypertension in offspring of lard-fed pregnant rats.

  title={Gender-linked hypertension in offspring of lard-fed pregnant rats.},
  author={Imran Y. Khan and Paul D Taylor and Vasia Dekou and Paul T Seed and Lorin Lakasing and Delyth Graham and Anna F. Dominiczak and Mark A. Hanson and Lucilla Poston},
  volume={41 1},
Epidemiological studies suggest an association between maternal nutrition and offspring cardiovascular disease. We previously demonstrated endothelial dysfunction and abnormal aortic fatty acid composition in adult female offspring of rats fed animal lard during pregnancy. We have now further investigated this model. Female Sprague-Dawley rats were fed a control breeding diet (5.3% fat) or a diet rich in lard (25.7% fat) 10 days before and throughout pregnancy and lactation. Male and female… CONTINUE READING