Gender differences in the metabolism of 1,3-butadiene in Sprague-Dawley rats following a low level inhalation exposure.

@article{ThorntonManning1995GenderDI,
  title={Gender differences in the metabolism of 1,3-butadiene in Sprague-Dawley rats following a low level inhalation exposure.},
  author={Janice R. Thornton-Manning and Ashley R. Dahl and William E. Bechtold and William C. Griffith and Lin Pei and Rogene F. Henderson},
  journal={Carcinogenesis},
  year={1995},
  volume={16 11},
  pages={
          2875-8
        }
}
1,3-Butadiene (BD), a compound used extensively in the rubber industry, is carcinogenic in the male and female Sprague-Dawley rats after chronic exposures to 1000 and 8000 p.p.m. In terms of incidence of tumors the majority were in mammary tissue, thus the incidence of tumors in female rats exceeded that in males in chronic carcinogenicity studies. In the present study the production and disposition of butadiene monoepoxide (BDO) and butadiene diepoxide (BDO2), mutagenic BD metabolites, were… CONTINUE READING

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