Gender differences in pharmacokinetics

  title={Gender differences in pharmacokinetics},
  author={Christoph H. Gleiter and Ursula M. Gundert-Remy},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
The is growing awareness that the underrepresentation of women in clinical trials and in particular in phase I studies may lead to incorrect handling of drugs. Despite the fact that investigations are not performed in a systematic way, there are a number of examples showing pharmacokinetic differences between gender. From the data actually presented, it can be concluded that the activity of CYP 3A4 activity as measured by elimination in vivo is higher in women compared to men. CYP isoenzymes… CONTINUE READING

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