Gender-differences in myocardial adaptation to afterload in normotensive and hypertensive rats.

@article{Wallen2000GenderdifferencesIM,
  title={Gender-differences in myocardial adaptation to afterload in normotensive and hypertensive rats.},
  author={W. Jack Wallen and Christine M Cserti and Michael Dine David P. Belanger and Carin Wittnich},
  journal={Hypertension},
  year={2000},
  volume={36 5},
  pages={774-9}
}
Echocardiographic studies suggest that women appear to exhibit a greater degree of myocardial hypertrophy in response to increased afterload than men. Therefore, gender differences and the role of estrogen and testosterone in the development of myocardial hypertrophy were studied in spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) rats. Male and female rats were either surgically neutered or underwent a sham operation at 21 days of age. A subgroup of neutered females of… CONTINUE READING