Gender differences in labetalol kinetics: importance of determining stereoisomer kinetics for racemic drugs.

@article{Johnson2000GenderDI,
  title={Gender differences in labetalol kinetics: importance of determining stereoisomer kinetics for racemic drugs.},
  author={Julie A. Johnson and Wendell S. Akers and V. Herring and Michael S. Wolfe and Jay M. Sullivan},
  journal={Pharmacotherapy},
  year={2000},
  volume={20 6},
  pages={622-8}
}
STUDY OBJECTIVE To evaluate the impact of gender on labetalol kinetics. DESIGN Part of a randomized, crossover study. SETTING Academic medical center. PATIENTS Nineteen hypertensive patients (14 men, 5 women; 6 blacks, 13 whites). INTERVENTIONS Participants had labetalol dosages titrated to a specific antihypertensive response, then underwent ambulatory blood pressure monitoring (ABPM) and a pharmacokinetic study. Labetalol plasma concentrations were measured by high-performance liquid… CONTINUE READING
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