Gender differences in 1,25 dihydroxyvitamin D3 immunomodulatory effects in multiple sclerosis patients and healthy subjects.

@article{Correale2010GenderDI,
  title={Gender differences in 1,25 dihydroxyvitamin D3 immunomodulatory effects in multiple sclerosis patients and healthy subjects.},
  author={Jorge Correale and Mar{\'i}a C{\'e}lica Ysrraelit and Mar{\'i}a In{\'e}s Gait{\'a}n},
  journal={Journal of immunology},
  year={2010},
  volume={185 8},
  pages={4948-58}
}
Vitamin D(3) is best known as a calcium homeostasis modulator; however, it also has immune-modulating potential. In this study, we demonstrated that immunomodulatory effects of vitamin D(3) are significantly stronger in females than in males in multiple sclerosis patients, as well as in healthy subjects. Inhibition of self-reactive T cell proliferation and reduction in IFN-γ- and IL-17-secreting cell numbers were considerably greater in females. Furthermore, the increase in IL-10-secreting and… CONTINUE READING
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