Gender difference in the role of endothelium-derived relaxing factors modulating renal vascular reactivity.

@article{Wangensteen2004GenderDI,
  title={Gender difference in the role of endothelium-derived relaxing factors modulating renal vascular reactivity.},
  author={Rosemary Wangensteen and Juan Manuel Moreno and J. A. Reche Sainz and Isabel Rodr{\'i}guez-G{\'o}mez and Virginia Chamorro and Juan de Dios Luna and A Osuna and F{\'e}lix Vargas},
  journal={European journal of pharmacology},
  year={2004},
  volume={486 3},
  pages={281-8}
}
UNLABELLED This study analyzed the role of nitric oxide (NO) and endothelium-derived hyperpolarizing factor (EDHF) in gender differences in the renal vascular reactivity of rats. Renal responses to vasoconstrictors and vasodilators were studied in isolated kidneys from male and female rats under basal conditions, after NO and EDHF blockade or after endothelium removal. Female rat kidneys had reduced responsiveness to vasoconstrictors. The blockade of NO or of EDHF did not completely abolish the… CONTINUE READING