Gender difference in the activity but not expression of estrogen receptors alpha and beta in human lung adenocarcinoma cells.

@article{Dougherty2006GenderDI,
  title={Gender difference in the activity but not expression of estrogen receptors alpha and beta in human lung adenocarcinoma cells.},
  author={Susan M. Dougherty and Williard Mazhawidza and Aimee R Bohn and Krista A Robinson and Kathleen A. Mattingly and Kristy A. Blankenship and Mary O'Malley Huff and William Glenn McGregor and Carolyn M Klinge},
  journal={Endocrine-related cancer},
  year={2006},
  volume={13 1},
  pages={113-34}
}
The higher frequency of lung adenocarcinoma in women smokers than in men smokers suggests a role for gender-dependent factors in the etiology of lung cancer. We evaluated estrogen receptor (ER) alpha and beta expression and activity in human lung adenocarcinoma cell lines and normal lung fibroblasts. Full-length ERalpha and ERbeta proteins were expressed in all cell lines with higher ERbeta than ERalpha. Although estradiol (E(2)) binding was similar, E(2) stimulated proliferation only in cells… CONTINUE READING

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