Gender difference in airway hyperresponsiveness in smokers with mild COPD. The Lung Health Study.

@article{Kanner1994GenderDI,
  title={Gender difference in airway hyperresponsiveness in smokers with mild COPD. The Lung Health Study.},
  author={Richard E. Kanner and John E. Connett and Murray D. Altose and A. Sonia Buist and W William Lee and Donald P Tashkin and Robert A. Wise},
  journal={American journal of respiratory and critical care medicine},
  year={1994},
  volume={150 4},
  pages={956-61}
}
Methacholine bronchoprovocation challenge testing was successfully completed in 5,662 participants (3,556 men and 2,106 women) at the time they were randomized into the Lung Health Study, a multicenter trial designed to evaluate early intervention in chronic obstructive pulmonary disease (COPD). All participants were smokers between the ages of 35 and 60 yr who had mild COPD. The male:female prevalence of a positive challenge (PC20FEV1) was 25%:48% and 63%:87% at a PC20FEV1 of < or = 5 mg/ml… CONTINUE READING
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