Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters

@article{Davey2011GenderdependentCO,
  title={Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters},
  author={Kieran J. Davey and Siobhain Mary O’Mahony and Harriet Schellekens and Orla O’Sullivan and John Bienenstock and Paul D Cotter and Timothy G Dinan and John F Cryan},
  journal={Psychopharmacology},
  year={2011},
  volume={221},
  pages={155-169}
}
Atypical antipsychotic drugs (AAPDs) such as olanzapine have a serious side effect profile including weight gain and metabolic dysfunction, and a number of studies have suggested a role for gender in the susceptibility to these effects. In recent times, the gut microbiota has been recognised as a major contributor to the regulation of body weight and metabolism. Thus, we investigated the effects of olanzapine on body weight, behaviour, gut microbiota and inflammatory and metabolic markers in… CONTINUE READING
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