Gender and manganese exposure interactions on mouse striatal neuron morphology.

@article{Madison2011GenderAM,
  title={Gender and manganese exposure interactions on mouse striatal neuron morphology.},
  author={Jennifer L. Madison and Michal Węgrzynowicz and Michael Aschner and Aaron B. Bowman},
  journal={Neurotoxicology},
  year={2011},
  volume={32 6},
  pages={896-906}
}
Gender differences in sensitivity and toxicokinetics of multiple metals have been identified in humans. A recent study suggested that young girls performed worse on intellectual exams than young boys exposed to manganese (Mn) in the environment. Animal studies have shown that Mn exposure causes differential effects on behavior in male compared to female mice. We hypothesized that in response to Mn exposure striatal Mn accumulation and/or striatal medium spiny neuron (MSN) morphology show gender… CONTINUE READING