Gender and duration of untreated psychosis: a systematic review and meta‐analysis

@article{Cascio2012GenderAD,
  title={Gender and duration of untreated psychosis: a systematic review and meta‐analysis},
  author={Maria Teresa Cascio and Matteo Cella and Antonio Preti and Anna Meneghelli and Angelo Cocchi},
  journal={Early Intervention in Psychiatry},
  year={2012},
  volume={6}
}
Aim: Duration of untreated psychosis (DUP) can influence the prognosis of schizophrenia. Previous studies have suggested that gender may influence the length of DUP. This study reports the result of the first systematic literature review and meta‐analysis on the role of gender in influencing DUP in first‐episode psychosis. 
Time delay in seeking treatment for first‐episode schizophrenia: a retrospective study
A longer duration of untreated psychosis (DUP) is associated with higher risk of relapse and a poorer overall prognosis. The study is designed to explore the duration of untreated schizophrenia and
Openness to experience shortens duration of untreated psychosis in Serbian clinical population
To determine duration of untreated psychosis (DUP) in patients with schizophrenia‐spectrum disorders from Serbia and to analyse factors that potentially contribute to the treatment delay, with focus
Examining gender difference in adult‐onset psychosis in Hong Kong
TLDR
A thorough examination on the gender differences in 360 Chinese patients with first‐episode psychosis in Hong Kong found mixed and inconclusive results regarding neurocognitive function and duration of untreated psychosis.
Entire duration of active psychosis and neurocognitive performance in first‐episode non‐affective psychosis
TLDR
DAP seems to be related to global neurocognitive impairment in FEP patients, and these findings contribute in several ways to the understanding of the effects of active psychosis on the brain.
Comparison of antipsychotic naïve first‐episode psychosis patients and healthy controls in Uganda
TLDR
The study compared the association of different risk factors in patients with first‐episode psychosis patients and healthy controls from an LMIC context.
Gender differences in patients with first‐episode psychosis in the Singapore Early Psychosis Intervention Programme
TLDR
The gender differences among multi‐ethnic, Asian patients with first‐episode psychosis attending the Early Psychosis Intervention Programme (EPIP) in Singapore were identified.
Factors contributing to the duration of untreated psychosis
Race, ethnicity, and the duration of untreated psychosis: a systematic review
TLDR
Racial and ethnic differences in DUP were rarely found, and three of ten studies suggested that Black patients generally, and Black-African patients specifically, may have a shorter DUP relative to White patients.
Gender differences in pathways to care for early psychosis
TLDR
Data from the ACE Pathways to Care Project, which examined pathways to care in African‐origin, Caribbean‐origin and European‐origin participants, is used to investigate the role of gender in pathways to early intervention programmes.
...
...

References

SHOWING 1-10 OF 92 REFERENCES
Duration of untreated psychosis and outcome in first‐episode psychosis. Perspective from a developing country
Objective:  To investigate the association between duration of untreated psychosis (DUP) and treatment outcome in a sample of subjects from a developing country.
Treatment delay and response rate in first episode psychosis
Objective:  There is no consistent evidence of long duration of untreated psychosis (DUP) predicting long time to response (TTR) in first psychosis. This study aims to investigate the predictors of
Measurement and reporting of the duration of untreated psychosis
TLDR
The aim of this study was to investigate the demographic, illness and methodological factors associated with mean and median duration of untreated psychosis (DUP) and to establish a cause-and-effect relationship.
Clinical and social determinants of a longer duration of untreated psychosis of schizophrenia in a Japanese population
Aim: To measure the duration of untreated psychosis (DUP) among patients with schizophrenia in a Japanese population and to investigate clinical and social determinants of the DUP.
The impact of substance use disorders on clinical outcome in 643 patients with first‐episode psychosis
TLDR
The main aim of the present study was to assess the impact of baseline SUD and course of SUD on remission of positive symptoms.
Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis.
TLDR
Shorter duration of untreated psychosis was associated with greater response to antipsychotic treatment, as measured by severity of global psychopathology, positive symptoms, negative symptoms, and functional outcomes.
Early intervention in psychosis: a retrospective analysis of clinical and social factors influencing duration of untreated psychosis.
TLDR
It is suggested that a longer DUP is influenced by the early clinical course and by social variables, and early recognition of these predictors of prolonged DUP should have an impact on reducing DUP and potentially improving the prognosis.
Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review.
TLDR
There is convincing evidence of a modest association between DUP and outcome, which supports the case for clinical trials that examine the effect of reducing DUP.
Negative symptoms in first episode non‐affective psychosis
TLDR
To determine the prevalence of negative symptoms and the role of specific negative symptoms in delay associated with seeking treatment in first episode non‐affective psychosis and to examine secondary sources of influence on negative symptoms.
Clinical and social determinants of duration of untreated psychosis in the AESOP first-episode psychosis study.
TLDR
Findings suggest that DUP is influenced both by aspects of the early clinical course and by the social context, with an insidious mode of onset associated with a substantially longer DUP compared with an acute onset.
...
...