Gender and age affect NK1 receptors in the human brain - a positron emission tomography study with [18F]SPA-RQ.

@article{Nyman2007GenderAA,
  title={Gender and age affect NK1 receptors in the human brain - a positron emission tomography study with [18F]SPA-RQ.},
  author={Mikko J. Nyman and Olli Eskola and Jaana Kajander and Tero Vahlberg and Sandra Sanabria and Donald H Burns and Richard Hargreaves and Olof Solin and Jarmo Hietala},
  journal={The international journal of neuropsychopharmacology},
  year={2007},
  volume={10 2},
  pages={219-29}
}
Substance P (SP) is a neurotransmitter and neuromodulator that mediates its effects in the brain predominantly via the neurokinin-1 receptors (NK1Rs). NK1Rs and SP have been shown clinically to be involved in nausea and emesis after chemotherapy (CINV) and have been implicated preclinically in a range of neuropsychiatric disorders but unlike CINV their blockade in these conditions does not have proven clinical value. We investigated whether age and gender affects NK1R binding potential (NK1R-BP… CONTINUE READING
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