Gender-affirming hormones and surgery in transgender children and adolescents.

  title={Gender-affirming hormones and surgery in transgender children and adolescents.},
  author={Simone Mahfouda and Julia K Moore and Aris Siafarikas and Timothy D Hewitt and Uma Ganti and Ashleigh Lin and Florian Daniel Zepf},
  journal={The lancet. Diabetes \& endocrinology},
  volume={7 6},

The effect of early puberty suppression on treatment options and outcomes in transgender patients

Puberty blockade is the earliest point of medical intervention indicated in paediatric patients expressing gender dysphoria and should be initiated as soon as signs of puberty are observed on physical examination, and has implications for fertility preservation, transgender surgical care and psychosocial health.

Managing Dermatologic Effects of Gender-Affirming Therapy in Transgender Adolescents

Improved understanding of the dermatologic impact of gender-affirming medical care such as pubertal suppression, hormone therapy, and surgeries can enhance patient outcome, and provision of patient-centered gender-Affirming care in dermatologic and multidisciplinary settings is essential.

Caring for Transgender and Gender Diverse Youth with Co-occurring Neurodiversity

Research points to an association between gender diversity and the clinical characteristics of autism spectrum disorder (ASD)/neurodiversity, and it has been suggested that gender dysphoria (GD) and

Deficiencies in Scientific Evidence for Medical Management of Gender Dysphoria

  • P. Hruz
  • Medicine
    The Linacre quarterly
  • 2020
The scientific evidence used to support current recommendations for affirming one’s preferred gender, halting normally timed puberty, administering cross-sex hormones, and surgically altering primary and secondary sexual traits are summarized and critically evaluated.

Psychosocial health in adolescents and young adults with gender dysphoria before and after gender-affirming medical interventions: a descriptive study from the Hamburg Gender Identity Service

How dimensions of psychosocial health were distributed among different intervention groups of adolescents with a GD diagnosis from the Hamburg Gender Identity Service before and after treatment is described to highlight the urgent need for further ongoing longitudinal research.

Quality of Life in Chilean Transgender Children and Adolescents

Introduction: Transgender (TG) children and adolescents experience problems in school as well as with family and social relationships that can adversely affect their physical and psychosocial health

Dermatologic considerations for transgender and gender diverse youth

The unique role pediatric dermatologists can play in the care of transgender and gender diverse youth including but not limited to treating acne and hair pattern changes as well as being knowledgeable about surgical and other cosmetic options for gender affirmation is highlighted.

Surgical Affirmation for Gender-Diverse Youth

Several major types of gender affirming surgeries are described, the guidelines outlined by the World Professional Association for Transgender Health are reviewed, practical surgical care concerns are covered, and best practice guidelines are addressed.

Hormone Therapy, Mental Health, and Quality of Life Among Transgender People: A Systematic Review

Hormone therapy was associated with increased QOL, decreased depression, and decreased anxiety, and Associations were similar across gender identity and age.



Approach to the patient: transgender youth: endocrine considerations.

  • S. Rosenthal
  • Psychology
    The Journal of clinical endocrinology and metabolism
  • 2014
Studies are reviewed that shed light on the biological underpinnings of gender identity, the epidemiology and natural history of transgenderism, current clinical practice guidelines for transgender youth, and limitations and challenges to optimal care.

Hormonal Treatment in Young People With Gender Dysphoria: A Systematic Review

GnRHa treatment was associated with improvement across multiple measures of psychological functioning but not gender dysphoria itself, whereas the psychosocial effects of gender-affirming hormones in transgender youth have not yet been adequately assessed.

Puberty suppression in gender identity disorder: the Amsterdam experience

From the studies that have been published thus far, it seems that the benefits outweigh the risks, however, more systematic research in this area is needed to determine the safety of this approach.

Youth and Caregiver Perspectives on Barriers to Gender-Affirming Health Care for Transgender Youth.

Cross-Sex Hormones and Metabolic Parameters in Adolescents With Gender Dysphoria

Testosterone use was associated with increased hemoglobin and hematocrit, increased BMI, and lowered high-density lipoprotein levels; estrogen was associatedWith lower testosterone and alanine aminotransferase levels; Otherwise, cross-sex hormone administration in adolescents was not associated with significant differences in the selected metabolic parameters over time.

Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People, Version 7

This version of the SOC recognizes that treatment for gender dysphoria has become more individualized, and can be used to help patients consider the full range of health services open to them, in accordance with their clinical needs and goals for gender expression.

Physiologic Response to Gender-Affirming Hormones Among Transgender Youth.