Gender-Dependence of Bone Structure and Properties in Adult Osteogenesis Imperfecta Murine Model

@article{Yao2013GenderDependenceOB,
  title={Gender-Dependence of Bone Structure and Properties in Adult Osteogenesis Imperfecta Murine Model},
  author={Xiaomei Yao and Stephanie M. Carleton and Arin D. Kettle and Jennifer R Melander and C L Phillips and Yong Wang},
  journal={Annals of Biomedical Engineering},
  year={2013},
  volume={41},
  pages={1139-1149}
}
Osteogenesis imperfecta (OI) is a dominant skeletal disorder characterized by bone fragility and deformities. Though the oim mouse model has been the most widely studied of the OI models, it has only recently been suggested to exhibit gender-dependent differences in bone mineralization. To characterize the impact of gender on the morphometry/ultra-structure, mechanical properties, and biochemical composition of oim bone on the congenic C57BL/J6 background, 4-month-old oim/oim, +/oim, and wild… CONTINUE READING