Gen(om)e duplications in the evolution of early vertebrates.

  title={Gen(om)e duplications in the evolution of early vertebrates.},
  author={Arend Sidow},
  journal={Current opinion in genetics & development},
  volume={6 6},
  • Arend Sidow
  • Published 1996 in Current opinion in genetics & development
Phylogenetic analyses and sequence surveys of developmental regulator gene families indicate that two large-scale gene duplications, most likely genome duplications, occurred in ancestors of vertebrates. Relaxed constraints allowed duplicated and thus redundant genes to diverge in a two stage mechanism. Neutral changes dominated at first but then positively selected regulatory changes evolved the novel and increasingly complex vertebrate developmental program.