Geminin is required for mitotic proliferation of spermatogonia.

  title={Geminin is required for mitotic proliferation of spermatogonia.},
  author={Kelly A. Barry and Kathryn M. Schultz and Christopher J. Payne and Thomas J. McGarry},
  journal={Developmental biology},
  volume={371 1},
Spermatogonial stem cells divide throughout life, maintaining their own population and giving rise to differentiated gametes. The unstable regulatory protein Geminin is thought to be one of the factors that determine whether stem cells continue to divide or terminally differentiate. Geminin regulates the extent of DNA replication and is thought to maintain cells in an undifferentiated state by inhibiting various transcription factors and chromatin remodeling proteins. To examine how Geminin… CONTINUE READING


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