Gemfibrozil is a potent inhibitor of human cytochrome P450 2C9.

Abstract

The in vitro inhibitory effects of gemfibrozil on cytochrome P450 (CYP) 1A2 (phenacetin O-deethylation), CYP2A6 (coumarin 7-hydroxylation), CYP2C9 (tolbutamide hydroxylation), CYP2C19 (S-mephenytoin 4'-hydroxylation), CYP2D6 (dextromethorphan O-deethylation), CYP2E1 (chlorzoxazone 6-hydroxylation), and CYP3A4 (midazolam 1'-hydroxylation) activities were… (More)

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Cite this paper

@article{Wen2001GemfibrozilIA, title={Gemfibrozil is a potent inhibitor of human cytochrome P450 2C9.}, author={X. Wen and J. S. Wang and Josefin Backman and Kari T. Kivist{\"o} and Pertti J Neuvonen}, journal={Drug metabolism and disposition: the biological fate of chemicals}, year={2001}, volume={29 11}, pages={1359-61} }