Gemfibrozil greatly increases plasma concentrations of cerivastatin

@article{Backman2002GemfibrozilGI,
  title={Gemfibrozil greatly increases plasma concentrations of cerivastatin},
  author={Janne T. Backman and Carl Kyrklund and Mikko Neuvonen and Pertti J. Neuvonen},
  journal={Clinical Pharmacology \& Therapeutics},
  year={2002},
  volume={72}
}
Concomitant use of gemfibrozil with statins, particularly with cerivastatin, increases the risk of rhabdomyolysis, but the mechanism of this potentially fatal drug interaction remains unclear. Our aim was to study the effect of gemfibrozil on cerivastatin pharmacokinetics. 
Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance
Risk of adverse events with fibrates.
The effect of gemfibrozil on the pharmacokinetics of rosuvastatin
Pharmacokinetic interactions between statins and fibrates.
Interactions of tizanidine with CYP1A2 enzyme inhibitors : Studies in vitro and in humans
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Effect of gemfibrozil on the pharmacokinetics and pharmacodynamics of racemic warfarin in healthy subjects.
TLDR
Usual therapeutic doses of gemfibrozil seem to have limited effects on the pharmacokinetics and pharmacodynamics of single dose warfarin in healthy subjects.
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TLDR
The aim of this study was to determine whether gemfibrozil affects the pharmacokinetics of simvastatin and whether it affects CYP3A4 activity in vitro.
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TLDR
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To the Editor: Bayer's voluntary withdrawal of cerivastatin from the U.S. market led to questions regarding the safety of all hydroxymethylglutaryl–coenzyme A reductase inhibitors, or statins.
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A series of studies were conducted to explore the mechanism of the pharmacokinetic interaction between simvastatin (SV) and gemfibrozil (GFZ) reported recently in human subjects. After administration
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TLDR
Clinically, this class of drugs appears to be most useful in lipoprotein disorders characterised by elevations of very low density lipop protein and plasma triglycerides, which are often accompanied by reductions in high densitylipoprotein (HDL) levels.
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