Gemcitabine chemotherapy induces phenotypic alterations of tumor cells that facilitate antitumor T cell responses in a mouse model of oral cancer.

@article{Tomihara2014GemcitabineCI,
  title={Gemcitabine chemotherapy induces phenotypic alterations of tumor cells that facilitate antitumor T cell responses in a mouse model of oral cancer.},
  author={Kei Tomihara and Hiroki Fuse and Wataru Heshiki and Rie Takei and Bin Zhang and Naoya Arai and Kenji Nakamori and Makoto Noguchi},
  journal={Oral oncology},
  year={2014},
  volume={50 5},
  pages={
          457-67
        }
}
OBJECTIVES Gemcitabine (GEM) is a pyrimidine nucleoside analogue that is a new chemotherapeutic agent used for treating various cancers. Because accumulating evidence indicates that GEM may activate host immune responses, its potential as an immune modulator in cancer chemotherapy has generated considerable interest. MATERIALS AND METHODS In the present study, we investigated the antitumor effects of GEM using a mouse oral cancer model using immunological analyses. We examined apoptotic cell… CONTINUE READING

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