Gemcitabine and carboplatin combination as first-line treatment in elderly patients and those unfit for cisplatin-based chemotherapy with advanced bladder carcinoma: Phase II study of the Hellenic Co-operative Oncology Group.

@article{Linardou2004GemcitabineAC,
  title={Gemcitabine and carboplatin combination as first-line treatment in elderly patients and those unfit for cisplatin-based chemotherapy with advanced bladder carcinoma: Phase II study of the Hellenic Co-operative Oncology Group.},
  author={Helena Linardou and Gerassimos Aravantinos and Eleni Efstathiou and Charalambos Kalofonos and Athanasios Anagnostopoulos and Charalambos Deliveliotis and Dimitrios Bafaloukos and Meletios Athanasios Dimopoulos and Aristotelis Bamias},
  journal={Urology},
  year={2004},
  volume={64 3},
  pages={
          479-84
        }
}
OBJECTIVES To evaluate, in a multicenter Phase II study, the safety and efficacy of the combination of gemcitabine and carboplatin, as first-line treatment in elderly and unfit patients with advanced bladder carcinoma. The toxicity of platinum-based chemotherapy combinations represents a common problem for elderly or unfit patients with advanced bladder carcinoma. METHODS Patients with previously untreated inoperable or metastatic bladder carcinoma and an Eastern Cooperative Oncology Group… CONTINUE READING

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