Gemcitabine--a novel immunosuppressive agent--prevents rejection in a rat cardiac transplantation model.

Abstract

BACKGROUND 2',2' -difluorodeoxycytidine (dFdC, gemcitabine) is a pyrimidine antimetabolite with antineoplastic activity against a wide range of solid tumors. The immunosuppressive activities of this compound have not been described to date. METHODS The in vitro effects on activated T lymphocytes were studied with a lymphocyte colony-forming assay in a… (More)

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