Gem: an induced, immediate early protein belonging to the Ras family.

@article{Maguire1994GemAI,
  title={Gem: an induced, immediate early protein belonging to the Ras family.},
  author={Jean E. Maguire and Tiberio Santoro and Peter Jensen and Ulrich Siebenlist and Jonathan W. Yewdell and Kathleen Kelly},
  journal={Science},
  year={1994},
  volume={265 5169},
  pages={
          241-4
        }
}
A gene encoding a 35-kilodalton guanosine triphosphate (GTP)-binding protein, Gem, was cloned from mitogen-induced human peripheral blood T cells. Gem and Rad, the product of a gene overexpressed in skeletal muscle in individuals with Type II diabetes, constitute a new family of Ras-related GTP-binding proteins. The distinct structural features of this family include the G3 GTP-binding motif, extensive amino- and carboxyl-terminal extensions beyond the Ras-related domain, and a motif that… CONTINUE READING

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The GTP binding proteins Gem and Rad are negative regulators of the Rho–Rho kinase pathway

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