Gelsolin gene therapy by retrovirus producer cells for human bladder cancer in nude mice

@article{Tanaka1999GelsolinGT,
  title={Gelsolin gene therapy by retrovirus producer cells for human bladder cancer in nude mice},
  author={Motoyoshi Tanaka and Ataru Sazawa and Nobuo Shinohara and Yoshiyasu Kobayashi and Yasunori Fujioka and Tomohiko Koyanagi and Noboru Kuzumaki},
  journal={Cancer Gene Therapy},
  year={1999},
  volume={6},
  pages={482-487}
}
Gelsolin, a regulator of the actin cytoskeleton, has been shown previously to act as a tumor suppressor in vitro and in vivo when introduced into certain cancer cell lines. To investigate the in vivo efficacy of gene therapy with the gelsolin gene, we inoculated nude mice with human urinary bladder cancer cells (UMUC-2 or DAB-1) and tested the effects of adding either retroviral DNA constructs containing gelsolin cDNA or retrovirus producer cells that produce the same retroviral constructs at… CONTINUE READING

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