Gelsolin and ADF/cofilin enhance the actin dynamics of motile cells.

  title={Gelsolin and ADF/cofilin enhance the actin dynamics of motile cells.},
  author={Frederick Seacrest Southwick},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={97 13},
M nonmuscle cells rapidly remodel their actin cytoskeleton to change shape as they crawl. The mechanisms underlying these dynamic changes in actin-filament concentration, length, and architecture have been the subject of extensive study for nearly three decades. Ameboid movements are complex and multidirectional, making analysis of individual cells difficult. Therefore investigators have tried to simplify their experimental models by (i) purifying individual proteins and analyzing their… CONTINUE READING
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