Gelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention.


Protein misassembly into aggregate structures, including cross-β-sheet amyloid fibrils, is linked to diseases characterized by the degeneration of post-mitotic tissue. While amyloid fibril deposition in the extracellular space certainly disrupts cellular and tissue architecture late in the course of amyloid diseases, strong genetic, pathological and… (More)
DOI: 10.3109/10409238.2012.661401


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