Gelsolin activity controls efficient early HIV-1 infection

  title={Gelsolin activity controls efficient early HIV-1 infection},
  author={Laura Garc{\'i}a-Exp{\'o}sito and Serena Ziglio and Jonathan Barroso-Gonz{\'a}lez and Laura de Armas-Rillo and Mar{\'i}a-Soledad Valera and Donato Zipeto and Jos{\'e}-David Machado and Agust{\'i}n Valenzuela-Fern{\'a}ndez},
HIV-1 entry into target lymphocytes requires the activity of actin adaptors that stabilize and reorganize cortical F-actin, like moesin and filamin-A. These alterations are necessary for the redistribution of CD4-CXCR4/CCR5 to one pole of the cell, a process that increases the probability of HIV-1 Envelope (Env)-CD4/co-receptor interactions and that generates the tension at the plasma membrane necessary to potentiate fusion pore formation, thereby favouring early HIV-1 infection. However, it… CONTINUE READING