Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells.

@article{Mabjeesh2002GeldanamycinID,
  title={Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells.},
  author={Nicola J. Mabjeesh and Dawn E. Post and Margaret T. Willard and B. Devinder Kaur and Erwin G Van Meir and Jonathan W. Simons and Hua Zhong},
  journal={Cancer research},
  year={2002},
  volume={62 9},
  pages={2478-82}
}
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor composed of alpha and beta subunits. HIF-1 is critically involved in cellular responses to hypoxia, glycolysis, and angiogenesis. Here, we show that treatment of prostate cancer PC-3 and LNCaP cells with the benzoquinone ansamycin geldanamycin, an Hsp90-specific inhibitor, induced degradation of HIF-1alpha protein in a dose- and time-dependent manner under both normoxia and hypoxia. This inhibition was also shown in… CONTINUE READING
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