Geldanamycin attenuates NO-mediated dilation in human skin.

@article{Shastry2002GeldanamycinAN,
  title={Geldanamycin attenuates NO-mediated dilation in human skin.},
  author={S Shastry and Michael J. Joyner},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2002},
  volume={282 1},
  pages={
          H232-6
        }
}
  • S. Shastry, M. Joyner
  • Published 2002
  • Biology
  • American journal of physiology. Heart and circulatory physiology
The binding of heat shock protein 90 (HSP90) to endothelial nitric oxide (NO) synthase (eNOS) can enhance eNOS activation. Studies have shown that the HSP90-specific inhibitor geldanamycin (GA) can cause attenuation of NO-mediated processes. Twenty subjects participated in one of two protocols. In each protocol, one forearm of each subject was instrumented with two intradermal microdialysis probes for drug delivery. Laser Doppler flowmeters were used to measure cutaneous blood flow. Skin sites… 
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TLDR
Passive heat therapy improves cutaneous microvascular function by improving NO-dependent dilation, which may have clinical implications.
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TLDR
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KCa channels and epoxyeicosatrienoic acids: major contributors to thermal hyperaemia in human skin
TLDR
The drug tetraethylammonium, when given in combination with nitric oxide synthase inhibition, blocked the majority of hyperaemia to local heat, indicating that endothelial‐derived hyperpolarizing factors are responsible for themajority of the remaining ∼40% ofhyperaemia.
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