Geldanamycin attenuates NO-mediated dilation in human skin.

  title={Geldanamycin attenuates NO-mediated dilation in human skin.},
  author={S. Shastry and M. Joyner},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={282 1},
  • S. Shastry, M. Joyner
  • Published 2002
  • Medicine, Biology
  • American journal of physiology. Heart and circulatory physiology
  • The binding of heat shock protein 90 (HSP90) to endothelial nitric oxide (NO) synthase (eNOS) can enhance eNOS activation. Studies have shown that the HSP90-specific inhibitor geldanamycin (GA) can cause attenuation of NO-mediated processes. Twenty subjects participated in one of two protocols. In each protocol, one forearm of each subject was instrumented with two intradermal microdialysis probes for drug delivery. Laser Doppler flowmeters were used to measure cutaneous blood flow. Skin sites… CONTINUE READING
    Endothelial nitric oxide synthase control mechanisms in the cutaneous vasculature of humans in vivo.
    • 119
    • Highly Influenced
    • PDF
    Heat shock protein 90 and tyrosine kinase regulate eNOS NO* generation but not NO* bioactivity.
    • 51
    • PDF
    Effects of hsp90 binding inhibitors on sGC-mediated vascular relaxation.
    • 21
    • Highly Influenced
    • PDF
    The Vasodilatory Response of Skin Microcirculation to Local Heating is Subject to Desensitization
    • 28
    • Highly Influenced
    • PDF
    KCa channels and epoxyeicosatrienoic acids: major contributors to thermal hyperaemia in human skin
    • 87


    Publications referenced by this paper.
    Role of nitric oxide in the vascular effects of local warming of the skin in humans.
    • 415
    • Highly Influential
    • PDF
    Hsp90 regulation of endothelial nitric oxide synthase contributes to vascular control in portal hypertension.
    • 144
    • Highly Influential
    • PDF
    Nitric oxide and neurally mediated regulation of skin blood flow during local heating.
    • 586
    • PDF
    Effects of atropine and L-NAME on cutaneous blood flow during body heating in humans.
    • 116
    • PDF