Geldanamycin attenuates NO-mediated dilation in human skin.

@article{Shastry2002GeldanamycinAN,
  title={Geldanamycin attenuates NO-mediated dilation in human skin.},
  author={S. Shastry and M. Joyner},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2002},
  volume={282 1},
  pages={
          H232-6
        }
}
  • S. Shastry, M. Joyner
  • Published 2002
  • Medicine, Biology
  • American journal of physiology. Heart and circulatory physiology
  • The binding of heat shock protein 90 (HSP90) to endothelial nitric oxide (NO) synthase (eNOS) can enhance eNOS activation. Studies have shown that the HSP90-specific inhibitor geldanamycin (GA) can cause attenuation of NO-mediated processes. Twenty subjects participated in one of two protocols. In each protocol, one forearm of each subject was instrumented with two intradermal microdialysis probes for drug delivery. Laser Doppler flowmeters were used to measure cutaneous blood flow. Skin sites… CONTINUE READING
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